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Clinical and other research trials are important to advance scientific knowledge about hypertensive disorders of pregnancy.

Periodically, the Preeclampsia Foundation makes arrangements with investigators to make enrollment information available about their studies. The following preeclampsia research trials have been approved by Institutional Review Boards. If you are interested in participating in one of the following studies, please contact the primary study investigator directly to inquire about enrollment. Listing of these studies on this site does not constitute an endorsement or recommendation by the Preeclampsia Foundation.

Preeclampsia survivors and those at risk for these pregnancy complications should seek to understand the benefits, alternatives and risks of participating in any research study, including those intended to study prevention or therapeutic interventions. Please know that the choice to participate in any research study is up to you.

Study Recruitments 

Research Study: Understanding the Patient Journey

Several preeclampsia researchers are collaborating with rEVO Biologics, a company developing a treatment for preeclampsia, to better understand the patient's journey through diagnosis, management, treatment, and delivery -- not necessarily in that order! Analyzing thousands of real-world patient experiences will help us to develop better education tools and processes, and to advocate to healthcare providers for improved patient engagement. This survey is being administered by The Preeclampsia Registry, a service of the Preeclampsia Foundation.

Only those who completed their first enrollment questionnaire to The Preeclampsia Registry will be eligible to take this survey. If you haven't finished your questionnaire, simply log-in to the Registry at www.preeclampsiaregistry.org and select "Finish a Questionnaire that I Started" from your MyRegistry page.

Research Study: Heart Health 4 Moms (HH4M)HH4M logo

Have you had a baby in the past 5 years? Was your pregnancy complicated by preeclampsia?

You may qualify for a research study that focuses on healthy behaviors to improve the long-term health of women who have had preeclampsia. This research is being conducted by Brigham & Women’s Hospital in Boston and the Preeclampsia Foundation. The study, Heart Health 4 Moms (HH4M), will be carried out online and will be accessible anytime, anywhere! Access to an internet-enabled smartphone or tablet is needed. You must live in one of the 50 U.S. states or one of the U.S. territories to be eligible. Up to $250 stipend provided.

Learn more at www.HH4M.org.

Research Study: PRESERVE-1

Goal: For women diagnosed with preeclampsia between 23 and 30 weeks:

  • Safely prolong pregnancy by delaying delivery
  • Improve outcomes of baby

Who can participate?

  • At least 16 years of age or older
  • Singleton pregnancy
  • 23 to 30 weeks pregnant with a recent diagnosis of preeclampsia or superimposed preeclampsia
  • Requiring monitoring in a hospital setting

Study Locations:
The PRESERVE-1 study will include 120 women at over 20 locations in North America.
Birmingham, AL
Mobile, AL
Little Rock, AR
Irvine, CA
New Haven, CT
Tampa, FL
Chicago, IL
Louisville, KY
New Orleans, LA
Detroit, MI
St. Louis, MO
New York, NY
Durham, NC
Cincinnati, OH
Oklahoma City, OK
Providence, RI
Chattanooga, TN
Houston, TX
Galveston, TX
Salt Lake City, UT
Norfolk, VA

Study Overview:
PRESERVE-1 is a Phase 3 clinical study for women who are diagnosed with preeclampsia between 23-30 weeks of their pregnancy. This study will assess if antithrombin (Recombinant), a man-made version of a naturally occurring blood protein, can increase the time that your baby stays in the womb, decrease the problems that you may experience or improve the health and well-being of your baby.

What to Expect:
Participation in this study will involve gathering your medical history, physical exams, blood and urine collection, taking the study medication, and monitoring for side effects under observation by a physician. Some participants will receive the medication and some participants will receive a placebo, which is a saline solution without active ingredients. Your baby will also be followed after delivery.

Learn more:

Putting Together the Preeclampsia Puzzle

We are working with external investigators to analyze data from The Preeclampsia Registry to answer a variety of research questions.

Have you or any of your family members EVER had preeclampsia or high blood pressure in pregnancy? 

Please consider enrolling in The Preeclampsia Registry at www.PreeclampsiaRegistry.org. Preeclampsia and related hypertensive disorders of pregnancy are life-threatening to the mother and her unborn baby. Your story, medical and pregnancy history, and ongoing health reporting will help scientists unravel all the pieces of this puzzle.

What is a Patient Registry?

Our goal is to have well over 10,000 participants including women directly affected, their sisters, and even friends who were not affected (to serve as “controls”). To learn more or enroll, go to www.PreeclampsiaRegistry.org. If you have questions, please email Registry@Preeclampsia.org.

In addition, ClinicalTrials.gov is a registry of most federally and privately supported clinical trials conducted in the United States and around the world. ClinicalTrials.gov gives you information about a trial's purpose, who may participate, locations, and phone numbers for more details. 

Investigators interested in our Study Participant Recruitment Services should contact the Preeclampsia Foundation at info@preeclampsia.org



The Preeclampsia Registry

    preeclampsia registry

    The Preeclampsia Registry is a "Living Database" bringing together those affected, their family members, and researchers to advance knowledge and discover preventions and treatments for preeclampsia, HELLP syndrome, and related hypertensive disorders of pregnancy.

Research Resources

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