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What happens biologically during Pre-E

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Re: What happens biologically during Pre-E

Post by bsherricca » Thu Aug 23, 2012 02:40 am

I just got my post pe 6 week blood test results back and they all came back as normal (except for slight anemia) ie i have no underlying conditions ...the tests they did were B2 Glocoprotien i and cadiolin AB ...are there other tests that should have been done ? are there other instances where women have had no underlying contions but still developed PE? ...

Re: What happens biologically during Pre-E

Post by MomTimesThree » Mon Jun 04, 2012 03:20 am

Just wondering if there was any research on why some pre-e is so quick moving and some so slow? Have any protective factors been discovered or is it all just luck of the draw?

Re: What happens biologically during Pre-E

Post by MomTimesThree » Thu Mar 29, 2012 04:08 am

This thread has been so interesting. I wondered if anyone knew if the etiology of super-imposed pre-e was different. If I understand correctly in "regular" PE it all originates from placenta issues. When you have super-imposed pre-e is that still the case? Or is it that because you have PIH, reach those pesky 140/90s and then are spilling protein which makes you pre-e diagnosable you get the label even though biologically the same thing isn't happening.

I hope this makes a lil' bit of sense. Our pre-e with our 2nd lil' one was so abnormal, and all our early labs placenta labs were normal (as they are this time around). Especially because with this lil' we were already spilling protein at 10weeks if last time was really super-imposed, even though I didn't have any blood pressure issues with my first, but maybe we would have if we had gone to term. Our bp is already starting to rise a lil' bit, now firmly trending in the 130s, and at a 2nd 24hr at 18 or 19 weeks creeping to 242. (If it goes any higher we'll be put on bp meds) I wonder if things continue progressing if this time around we would get a super-imposed label. Though gosh... I hope all this thinking about this is all for nothing and we get a pregnancy without any diagnosis except for pregnant with big fat full term healthy baby.

Re: What happens biologically during Pre-E

Post by Sara35 » Tue Mar 27, 2012 03:39 am

Thank you so much. I am pretty scared at the moment. Am 36+2 and have been watched non stop since 32 weeks as protein in urine with raised BP which slowly raised enough to 160/103 last week that they put me on labetolol...200mg twice a day which brought bp down to 120/77 average. Today went in and it was 139/90 so am having an extra dose of labetolol. Have been told to come back in for monitoring and then if all well, they will give me a sweep at 37+2 (a week today). I am just a little nervous because the last 4-5 weeks have been a haze as been checked so often and am constantly linking every pain and strain to PE, feel like a hypochondriac.

Re: What happens biologically during Pre-E

Post by caryn » Wed Mar 21, 2012 12:56 am

Re: What happens biologically during Pre-E

Post by momof4as » Wed Mar 21, 2012 12:49 am

I was told that they are studying a link between the genetics with the Father that could be contibuting to pe in the mother... any news on this? I makes sense since I had two children without PE and both kids with my husband I've had PE with.

Re: What happens biologically during Pre-E

Post by smz1789 » Mon Feb 27, 2012 08:27 am

So glad I found this post... I learned more about what pre-e really is in this single thread, then I've ever heard in a doctors office, or read in a pregnancy book!
Thank you for sharing this insight ladies!

Re: What happens biologically during Pre-E

Post by caryn » Wed Jun 01, 2011 11:12 am

I think IUGR is something they'll watch for simply because the correlation between PE and IUGR is known to be very strong, likely due to the shallow implantation. They're watching for horses, not zebras, and so they'll watch for IUGR.

But yeah, superimposed preeclamptics with bigger babies - ie a lot of us chronics - are probably pulling off some other set of problems that just look similar. Oscar was almost 5 pounds at 34 weeks, and in a normal pregnancy, would have doubled his weight between 34 weeks and delivery. So a 10-pound firstborn. I *really really suspect* that the maternal-fetal conflict issue in my case was simply that my body tried to modulate bloodflow downward from a normal (or perhaps deeper than normal) implantation and the placenta fought back, triggering the whole PE spiral. (My husband and I are both bossy sorts, by the way.)

Re: What happens biologically during Pre-E

Post by alexis » Tue May 31, 2011 12:35 am

caryn wrote:This is very difficult to study, but it's an ongoing, very intriguing, area of research. One thing that I find fascinating about it is that some chronics have babies who are *big* for gestational age, which might suggest that even though the placenta is shallowly implanted it's developing a decent blood supply anyway, or might suggest that implantation is deep enough to grow a big baby but at the same time the maternal immune response to it is creating hypoxia and triggering the same downstream effects that a shallow implantation would cause. There are multiple pathways operating here, multiple placental strategies for maximising bloodflow, so you could simultaneously have shallow implantation and then other strategies that compensated somewhat for that shallow implantation, like upregulation of maternal respiration rate and heart rate and appetite (so the little blood that does make it 'round to perfuse the placenta is still packed with supplies. (I think this is a useful way to explain tachycardia and breathlessness in some PE patients.)

Ok - this intrigues me.

Baby #1 - 8lbs1oz at 37 weeks. I had fewer growth scans, but I remember she was measuring a week ahead at 12 and 20 weeks (and I'm sure about my dates)
Baby #2 - EFW over 1 lb at 20 weeks; I forgot to ask percentiles, but I think I saw something on-screen about 95th percentile. Currently 22 weeks, so outcome is open. On Toprol this pregnancy but not with #1.

Everyone (my providers included) seems concerned about IUGR and blood flow to the fetus. But I wonder: If my history is that I manage to both have superimposed PE and grow a very nicely sized baby in the past, how should I apply that to my current pregnancy? Does it have any relevance at all?

Re: What happens biologically during Pre-E

Post by caryn » Wed Feb 16, 2011 07:37 am

This test is in development in the US. A similar one (not as accurate as what will be needed to meet regulatory requirements here) is available now in Europe.

Since you've already had PE, your care providers will already be on high alert, so I'm not certain that this test has a whole lot of value for women with a history. There's no treatment yet, and what this test does is alert you to the likelihood of complications. But you're already alert!

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