FAQ Members Login

Pathogenesis of preeclampsia: the genetic component

Post a reply

:
In an effort to prevent automatic submissions, we require that you enter both of the words displayed into the text field underneath.
Smilies
:D :) ;) :( :o :shock: :? 8-) :lol: :x :P :oops: :cry: :evil: :twisted: :roll: :!: :?: :idea: :arrow: :| :mrgreen: :geek: :ugeek:
BBCode is ON
[img] is ON
[flash] is OFF
[url] is ON
Smilies are ON
Topic review
   

If you wish to attach one or more files enter the details below.

Expand view Topic review: Pathogenesis of preeclampsia: the genetic component

Re: Pathogenesis of preeclampsia: the genetic component

Post by caryn » Sat Jan 07, 2012 10:53 am

On a deep cellular level none of us like each other. Everyone else is foreign and the immune system says ATTACK!

The odd thing about pregnancy is that his genes somehow manage to instruct us to dial that down, and we cooperate with him until we don't, any more. Which is what triggers labor. Except if we decide to trigger labor and get the kid out, but the placenta fights back because it isn't done cooking yet...

Re: Pathogenesis of preeclampsia: the genetic component

Post by MissingMolly » Sat Jan 07, 2012 03:20 am

So is this sort of like "the perfect storm" for preeclampsia? It seems very much to be a dynamic reaction between the two systems (maternal and paternal). Does that mean that, on some deep cellular level, my husband and I don't "like" each other?
:shock:

Re: Pathogenesis of preeclampsia: the genetic component

Post by caryn » Wed Dec 21, 2011 07:25 am

"multifactorial polygenic inheritance" means you have to hit on a combination of genes in the mother and a combination of genes in the father. So say I had to have the genes for chronic hypertension plus an immune mediated condition, and DH had to have the genes for a slightly deranged implantation, and when you put all of those together, the phenotype expresses preeclampsia.

Re: Pathogenesis of preeclampsia: the genetic component

Post by cmccaffrey » Tue Dec 20, 2011 10:48 am

same with my family history, Kerisue!

Re: Pathogenesis of preeclampsia: the genetic component

Post by kerisue » Tue Dec 20, 2011 10:26 am

but then again no one in my entire family has ever had it as far back as we can determine which is several generations. fob's side either. (though there is general hypertension in the family)

Pathogenesis of preeclampsia: the genetic component

Post by caryn » Sun Dec 18, 2011 05:13 am

From an epidemiological point of view, many studies have shown that PE is a disease with a strong familiar predisposition, which also varies according to geographical, socioeconomic, and racial features, and this information can be used in the prediction process. Large amounts of research have shown a genetic association with a multifactorial polygenic inheritance in the development of this disease.

http://www.ncbi.nlm.nih.gov/pubmed/22175024

Yep, my sister and I both had it, and I've a strong family history of chronic hypertension. DH's brother fathered a child with severe IUGR, so his family makes weird placentas. The combination? Not so awesome.

Top

cron