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Cellular Fetal Microchimerism in Preeclampsia

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Expand view Topic review: Cellular Fetal Microchimerism in Preeclampsia

Re: Cellular Fetal Microchimerism in Preeclampsia

Post by chal4oye » Fri Jan 31, 2014 04:54 am

Or maybe this is co-incidental? Maybe more fetal DNA in circulation equals more autoimmune disorders, which tend to be risk factors for preeclampsia. Just wondering...

Re: Cellular Fetal Microchimerism in Preeclampsia

Post by alviarin » Wed Nov 06, 2013 12:02 am

Makes sense, thanks!

Re: Cellular Fetal Microchimerism in Preeclampsia

Post by caryn » Thu Oct 31, 2013 12:57 am

It has to do with the initial invasion not being "seen" properly by our immune systems, I think. The leaky vasculature should just leak into the interstitial spaces between the cell walls, not into the maternal bloodstream.

The autoimmune disorders are a cause/effect problem. Do we have autoimmune disorders because we have odd immune systems which predispose us to preeclampsia? Does exposure to foreign human proteins because of odd invasion trigger autoimmune disease?

Re: Cellular Fetal Microchimerism in Preeclampsia

Post by alviarin » Mon Oct 28, 2013 12:03 am

Could this increase be caused by preeclampsia? (Since we have leakier blood vessels, and higher pressures....)

Or maybe this is co-incidental? Maybe more fetal DNA in circulation equals more autoimmune disorders, which tend to be risk factors for preeclampsia. Just wondering...

Re: Cellular Fetal Microchimerism in Preeclampsia

Post by caryn » Thu Oct 24, 2013 09:42 am

Yes, and no. They don't do a quantitative count. But this suggests that if they *did*, those tests might have some utility as screening tests for preeclampsia. Probably a pretty low sensitivity though, because not every member of the population of preeclamptics showed an increase in fetal microchimerism, even if the population as a whole showed a very large increase.

Re: Cellular Fetal Microchimerism in Preeclampsia

Post by angieb » Wed Oct 23, 2013 09:01 am

Interesting.

Would these be the same fetal cells that are tested from the mother's blood in the newest (Maternti21 / Harmony) genetic tests? Would it throw off those results?

Cellular Fetal Microchimerism in Preeclampsia

Post by caryn » Wed Oct 23, 2013 09:25 am

"We conclude that women with preeclampsia harbor cellular fetal microchimerism more commonly and at higher concentrations compared with women with uncomplicated pregnancy. The functional capacity and phenotype of these fetal cells are not yet known."

http://www.ncbi.nlm.nih.gov/pubmed/24101661

So more of the fetal cells get into our circulation than in normal pregnancy, and we don't know why they're there, or what they're doing. They might be affecting our metabolism, or triggering a stronger immune reaction, or repairing damage from pregnancy, or mucking with our thyroids, or any number of other possibilities.

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