Prothrombin gene G20210A mutation & obstetric comp

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Expand view Topic review: Prothrombin gene G20210A mutation & obstetric comp

Prothrombin gene G20210A mutation & obstetric comp

Post by caryn » Tue Dec 29, 2009 09:06 am

There was no association between the prothrombin G20210A mutation and pregnancy loss, preeclampsia, abruption, or SGA neonates in a low-risk, prospective cohort. These data raise questions about the practice of screening women without a history of thrombosis or adverse pregnancy outcomes for this mutation.

http://www.ncbi.nlm.nih.gov/pubmed/20027028

As opposed to the other study I just posted, this study says the prothrombin mutation *doesn't* raise risk. So dueling studies, yay! I'll have to take a good look at them both and see how they controlled their variables etc., but my instinct is to run with this one until proven otherwise simply because a) some big familiar names are authors on the paper and b) some other work has been weakening the association with thrombophilias and pregnancy complications.

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