doença renal e pré-eclâmpsia Kidney disease and preeclampsia

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Expand view Topic review: doença renal e pré-eclâmpsia Kidney disease and preeclampsia

doença renal e pré-eclâmpsia Kidney disease and preeclampsia

Post by tafacca » Mon Feb 28, 2011 04:19 am

A proteinúria é provavelmente a principal causa de doença renal na pré-eclâmpsia. O seu nível está diretamente relacionado a um pior prognóstico materno e perinatal e maior risco de desenvolver complicações como eclâmpsia e síndrome HELLP (hemólise, enzimas hepáticas elevadas e plaquetopenia).
O acometimento renal na pré-eclâmpsia está associado à podocitopatia. O podócito é uma célula do rim que participa do processo de filtração de proteínas. A sua lesão pode desencadear a sua perda na urina (podocitúria) podendo levar à glomeruloendoteliose que clinicamente se manifesta por proteinúria e consequentemente à doença renal aguda ou até crônica.
Proteinuria is probably the main cause of kidney disease in preeclampsia. Its level is directly related to a poor maternal and perinatal outcomes and increased risk of developing complications such as eclampsia and HELLP syndrome (hemolysis, elevated liver enzymes and thrombocytopenia).
The renal involvement in preeclampsia is associated with podocitopatia. The podocytes are cells in the kidneys that participate in the process of filtration of proteins. Its injury may cause the loss in the urine (podocyturia) and glomeruloendoteliosis that leads to proteinuria and consequently to acute kidney disease or even chronic.

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