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 Announcements and Preeclampsia in the News
 Increased levels of cell-free hemoglobin, oxidatio
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Caryn
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CarynFamily
USA
7654 Posts

Posted - 11/04/2009 :  12:13:14 PM  Show Profile  Reply with Quote
The mean plasma concentrations of HbF, HbA, protein carbonyl groups, membrane peroxidation capacity and alpha(1)-microglobulin were significantly increased in preeclamptic women. The levels of total plasma Hb correlated strongly with the systolic blood pressure. The plasma haptoglobin concentrations of women with preeclampsia were significantly depressed. Increased amounts of alpha(1)-microglobulin-mRNA and protein were found in placenta from preeclamptic women and the levels of plasma and placenta alpha(1)-microglobulin correlated to plasma Hb-concentrations...

http://www.ncbi.nlm.nih.gov/pubmed/19879940

Hmmm. That might have something to do with the rarity of anemia diagnoses among preeclamptics. We've got significantly higher bloodstream levels not just of maternal hemoglobin, but fetal as well -- and also higher levels of the oxidative markers associated with hemoglobin.

Information provided on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disorder, or prescribing any medication. The Preeclampsia Foundation presents all data as is, without any warranty of any kind, express or implied, and is not liable for its accuracy, for mistakes or omissions of any kind, nor for any loss or damage caused by a user's reliance on information obtained on the site. Professional opinions on this condition vary greatly. The Preeclampsia Foundation endorses no one course of treatment or "cure".

mother bear
Junior Member

US
226 Posts

Posted - 11/04/2009 :  1:40:00 PM  Show Profile  Reply with Quote
See, that makes me feel better already. Just being diagnosed as anemic last week decreases my chances this time around.

Mommy to Michelle 1/06 - 31 weeks due to Severe pe, placental abruption, IUGR
homozygous MTHFR C677T
Nicole 9/07 - 39 weeks 2 days PIH and white coat tachycardia, but NO PE!
#3 is a boy! C-section scheduled 1-14-10, on 2 LDA, 4mg folic acid, extra iron, synthroid, and 12.5mg Atenolol once a day.
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jules2
Junior Member

UK
147 Posts

Posted - 11/05/2009 :  09:10:21 AM  Show Profile  Reply with Quote
That really bad news for me, with a Hb of 15 which always goes UP not down when pregnant. Maybe this pregnancy is doomed already?

Mother to Alice, stillborn on 05/09/09 at 26+1 weeks

Missed miscarriage at 8 weeks, Nov 2009
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Caryn
Ask the Experienced Moderator

CarynFamily
USA
7654 Posts

Posted - 11/05/2009 :  12:14:23 PM  Show Profile  Reply with Quote
It's a correlation, and they don't really understand the significance of it yet. My Hb goes up too, but I got to 34 weeks...

Science is getting us closer to finding a cause, and even a cure. The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies?
Caryn, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
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marymom
Starting Member

US
2 Posts

Posted - 11/09/2009 :  09:59:13 AM  Show Profile  Reply with Quote
Hello, I am Mary, a second year midwifery student seeking my FL state midwifery license (laywoman's terms I will become a homebirth midwife)We do not care for pre eclamptic mammas -rather our objective would be to identify in a timely way, any illness and get mom into medical care so- here I am to learn.
I also write as a grandmother who just saw (late August) her daughter treated for pre eclampsia- and have attended births in the hospital for mammas w/ pre eclampsia-
I will be cruising your forums and your CME pages as Im writing about preeclampsia, please feel free to direct me to anything you believe should be looked at by future midwives :)
warmly, ~mary
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Caryn
Ask the Experienced Moderator

CarynFamily
USA
7654 Posts

Posted - 11/09/2009 :  7:55:25 PM  Show Profile  Reply with Quote
Welcome to the forums, Mary.

The links in my .sig are a good place to start. Another useful source for management of preeclamptics with transfer guidelines is the British PRECOG, or the Pre-Eclampsia Community Guideline.

Feel free to holler with any questions; this place is huge. :-)

Science is getting us closer to finding a cause, and even a cure. The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies?
Caryn, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
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marymom
Starting Member

US
2 Posts

Posted - 11/10/2009 :  10:24:17 AM  Show Profile  Reply with Quote
you have angel wings sprouting from your back... the Precog will be perfect to have onhand at the school-
I am crawling out of my Blue Ribbon baby cave and gasping...
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Blythe
Ask the Experienced Moderator

heather
USA
2081 Posts

Posted - 11/10/2009 :  1:25:46 PM  Show Profile  Reply with Quote
Welcome, Mary! Like Caryn said, we have tons of information and experiences to share. I'm a natural-birth crunchy gal, but over the years on these boards and my own experiences, I've had quite a few of those "out of the cave and gasping" moments :-D. Let us know if you get overwhelmed or if we can help in any way!

Heather - mom to
DS #1 - 7/18/03, 37 weeks - Mild PE, 5lbs, 8oz, 4 days in NICU
DS #2 - 8/11/06, 36 1/2 weeks, 6lbs, 14oz!!! Induced for diagnostic BP. No NICU!
DD #3 - 9/10/09, high bp at 33 1/2 weeks, induced at 37 weeks, 5 pounds, 12 ounces - healthy girl!
"Thank God for the internet - otherwise my children would be raised in a med school library"
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