Preeclampsia at 18 weeks

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joker
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Re : Preeclampsia at 18 weeks

Postby joker » Fri Jul 20, 2007 10:15 pm

I just learned of the preliminary autopsy report for my little girl...She had a cystic hygroma at the back of the neck (but right now they can't say why, since they originally thought it was becuase of Turner's Syndrome), and that she had an enlarged heart and liver with excessive fluids in the skin that are indicitive of heart failure. But so far cannot find any genetic problems.
J

ecfeeney
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Re : Preeclampsia at 18 weeks

Postby ecfeeney » Thu Jul 19, 2007 05:28 am

Jennifer,

I am very very sorry for the loss of your daughter,

Elaine

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rosemary
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Re : Preeclampsia at 18 weeks

Postby rosemary » Thu Jul 19, 2007 01:05 am

Jennifer,

I am so sorry for the loss of your daughter. Like you, I only have one good functioning kidney. I actually never knew that I had kidney issues until about a year after having PE. My kidney issue was due to a birth defect that went undetected and shrunk my left kidney making it almost non-functional. One of my first questions to my nephrologist was 'did my kidney issues have any role in my PE?' I was told no, but after lots of reading, I do feel that my kidney defects played a role. Along with my kidney issues, I also had other things that didn't help, being overweight and being over 40.

Again, I am terribly sorry for your loss. I do hope that you find some answers that can give you some peace.


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julie f
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Re : Preeclampsia at 18 weeks

Postby julie f » Thu Jul 19, 2007 00:42 am

Jennifer,

I just wanted to tell you that I am so very sorry for your loss.

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caryn
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Re : Preeclampsia at 18 weeks

Postby caryn » Wed Jul 18, 2007 02:11 pm

As Fiona said, there are thought to be links between genetic abnormalities and PE:
http://www.preeclampsia.org/forum/viewtopic.php?t=20108

But I am not finding anything on fetal abnormalities that are *not* genetic and PE, at least not yet.

I suppose that a lot of the switches that control fetal growth could be working poorly if the placenta implanted poorly -- lower than normal levels of proteins that controlled expression of enzymes etc. -- and poorly implanted placentae are thought to often be causal in severe PE cases. I don't know.

I've also found a few replies from our Experts on patients with one kidney or with kidney disease. Although none of them are for women with a history of Wilm's Tumor, it would give you some idea of what they tend to look at:
http://www.preeclampsia.org/forum/viewtopic.php?t=22387
http://www.preeclampsia.org/forum/viewtopic.php?t=840
http://www.preeclampsia.org/forum/viewtopic.php?t=3941
http://www.preeclampsia.org/forum/viewtopic.php?t=1321
http://www.preeclampsia.org/forum/viewtopic.php?t=1125

I'm so sorry you have had to find us under these circumstances. You'll be in my thoughts.

for faith
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Re : Preeclampsia at 18 weeks

Postby for faith » Wed Jul 18, 2007 01:47 pm

J - I am so sorry for the loss of your little girl. This is a great site for lots of info and unfortunately many of us have had losses here. I hope that you are able to get some answers with everything. Thinking of you......

lisainnj
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Re : Preeclampsia at 18 weeks

Postby lisainnj » Wed Jul 18, 2007 12:29 am

I am so sorry about the loss of your little girl, and hope you can find some answers as to what went wrong.

Were your doctors able to do any genetic study for your baby, or just count her chromosomes? (Trisomy 13 is linked to a high PE risk but that wasn't the problem here.)

There is a reference for increased birth defect risk for relatives who survived Wilm's tumor here.

http://www.ncbi.nlm.nih.gov/sites/entre ... t=Abstract

It may feel like another kick in the gut - I recently found out that my own PE (lost my little girl at 20 weeks) was caused by an inherited condition that can cause other life-threatening problems and I have to watch out for them in myself and my children. It sucks. But if I didn't know it would be worse, and was worse.

I hope you and your husband can find your answers and pray the answers are good.

fiona
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Re : Preeclampsia at 18 weeks

Postby fiona » Wed Jul 18, 2007 11:43 am

J, welcome - I'm glad you've found us. I am so sorry for the loss of your daughter and all the complications to your pregnancy. Full blown pe at 18 weeks is extremely rare, but we have at least one member who went through the same and many of us - myself included - have had pregnancies where pe developed before the 20 week mark.

As to your questions: pre-existing kidney disease is a risk factor for preeclampsia, however, if your one kidney is working fine, I'm not sure that would necessarily be an issue.

There are links between genetic defects of the baby and pe, and I will endeavor to look for some more info on that subject for you.

What have your specialists said? Have you discussed the possibility of another pregnancy with them? They may want to run a bunch of tests to pinpoint any other underlying disorders that put you at risk for pe - and look at ways to mange them through a future pregnancy.

Please know that many of us have walked in your shoes and we understand the fear and longing that swamps you after losing a baby to preeclampsia. You will find lots of support here, whatever your decision.

Take care.


joker
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Preeclampsia at 18 weeks

Postby joker » Wed Jul 18, 2007 11:15 am

I recently went into severe preeclampsia at 18 weeks, had to have labor induced and delivered a stillborn daughter. My daughter had multiple birth defects including severe heart defect, limb defects and a cystic hydroma and was originally diagnosed with Turner's Syndrome. We had an Amnio done, and within a day, was admitted to the hospital and the diagnosed with preclampsia. The final amnio results showed no genetic abnormalities such as Turner's Syndrome. To further complicate things, I am an adult survivor of Wilm's Tumor and only have one kidney. This was my first pregnancy, and everything that could go wrong did.

I am wondering if there is any link between only having one kidney and preclampsia and if there is any evidence that babies with multiple defects can increase the mother's risk for preeampsia. I was lucky enough to be treated by some of the top maternal-fetal specialists in my area, but they have said that preeclampsia at 18 weeks is extremely rare.

My husband and I are overwhelmed with everything that has happened and are looking for any answers that might help us to decide if another pregnancy should even be an option for us.
J


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