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Acute and Transient Podocyte Loss and Proteinuria

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Acute and Transient Podocyte Loss and Proteinuria

Postby caryn » Tue Apr 28, 2009 02:14 am

by caryn (10131 Posts), Tue Apr 28, 2009 02:14 am

...Statistics indicated a correlation between urinary podocyte number and blood pressure, but not with proteinuria. In conclusion, podocyturia in preeclampsia is transient and almost synchronous with heavy proteinuria. The results suggest that acute podocyte loss implicates podocyturia as the possible mechanism of proteinuria in women with preeclampsia...

http://www.ncbi.nlm.nih.gov/pubmed/19390204

In other words, maybe our non-specific proteinuria (it's not just, say, albuminuria, but general proteinuria) is actually podocyturia. Which means that what we're *actually* spilling are the cells that line the blood vessels in the kidneys. Preeclampsia mucks up the kidneys generally -- we develop holes in the glomeruli -- so this makes a certain amount of sense, and it also might help explain the fraction of women who have permanent kidney damage postpartum, if the blood vessels were damaged beyond repair.

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