Intro- New here - cholestasis and proteinuria?

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Re: Intro- New here - cholestasis and proteinuria?

Postby barbimola » Sun Feb 19, 2012 03:32 pm

Thank you very much for your responses, I'll keep you posted. So far my BP readings are a little higher but under control.
Let see how long I can hold them in my belly. Doctors say I will stay in the hospital until delivery. I'll try and stay calm. Today is week 30.3
Thanks for your support!

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Re: Intro- New here - cholestasis and proteinuria?

Postby alexis » Sun Feb 19, 2012 01:43 pm

I believe multiples raise risk of cholestasis as well as PE--I know someone else who had both, with a triplet pregnancy.

Because your BP rose before, your hypertension may be chronic, not gestational (the normal cutoff is 20 weeks, but I don't know if multiples changes that equation). Methyldopa is very well studied in pregnancy--it's actually FDA category B. I would think that if an association between methyldopa use and cholestasis existed it would have been reported by now.
Chronic hypertension
Aliza - 01/05/2007 - Severe preeclampsia, emergency CS 37 weeks
Isaac - 09/26/2011 - controlled on 150mg Toprol, NO PE, 39 weeks!

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Re: Intro- New here - cholestasis and proteinuria?

Postby caryn » Sun Feb 19, 2012 12:03 am

Hello! I moved your post to this new thread so more people would see it and you might get more replies.

With pressures of 140/85 and proteinuria of ~900mg in a 24 hour catch, you're already preeclamptic - the definition just requires two readings of either of 140/90, and 300 mg in 24 hours.

Cholestasis is a kind of immune response to the foreign placenta - or in your case possibly placentas! - so it isn't caused by the medication.

I'm glad you're in the hospital being monitored so closely, and have already had the steroids. Twins are rough when you already have a history of preeclampsia, since they make you higher risk. I hope you get some more safe time to be pregnant. Please keep us posted as you're able!
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
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Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy

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Intro- New here - cholestasis and proteinuria?

Postby barbimola » Sat Feb 18, 2012 04:33 pm


I don't know if you read my post yesterday in response to Katie.
I'm still in the hospital, when I arrived 9 days ago due to cholestasis, my proteinuria was 200 in the 24hr test, today it came back 900. Is that bad?
I've been on metyldopa (250 x 3 day) since week 17 for gestational High Blood pressure, but since I've been in the hospital they taken me of the drug and my BP reading have been great. 12/7 - 14/85. Amazing!!!! Makes me wonder if it was wrong to take meds for so long, maybe the cause of cholestasis??
Could I be starting PE. I'm 30.2 weeks pregnant of twins.
I am not being discharged because my bile acids are too high and docs say I could get a c-section any moment.Too early too induce.
I feel fine. Both baby boys are monitored and fine. I am a little worried.
Thank you!!!

Mom (35) Dad (37)
1 daughter 2-27-2005 PE week 40
2 daughter 3-14-2007 Induced 37.5 PE
Miscarriage Molar pregnancy 26-12.2007
3 daughter 2-22-2009 c-section 36 weeks Eclampsia

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