blood type and PE

[expert@preeclampsia.org]

My daughter developed pre-eclampsia with her first pregnancy at 2 days prior to delivery on her normal due date. Now that she is pregnant with her second child I am concerned that it may happen again.

I have wondered ever since my daughter's first pregnancy, if there is any correlation between this happening to her and her father and I having opposite blood types. I am B negative and her father A positive. I received the Rhogam injection immediately after her birth and breastfed her for 4 months.

I do not know if in any of the research case studies family history questions have include that type of information.

[expert@preeclampsia.org]

I know of no credible body of data which lends credence to Rh factor, either negative or positive, as important to the pathogenesis of preeclampsia or risk of disease development. At the recent ISSHP meeting in Lisbon, a group from The Netherlands presented data which found no association between major blood groups (ABO genotype) and risk of developing either early onset preeclampsia or HELLP syndrome (Bruinse's group).