Back in 2002 my first pregnancy was going exactly as planned until I developed preterm labor at 32 wks. At 34 wks I then developed severe atypical preclampsia and HELP Syndrome. I was taken by life flight for an emergency C-section since I live in a smaller community. Immediately prior to delivery I was distraught to find out that I had no amniotic fluid and my daughters kidneys had shut down. Luckily, after birth my daughterÃ¢â‚¬â„¢s kidneys began functioning normally and she now a very healthy two year old.
Genetic testing has since revealed I am homozygous for the MTHFR mutation. I was initially told after delivery that I would be treated with low dose aspirin and Heparin therapy with any subsequent pregnancies.
My husband and I just met with the Maternal-Fetal Medicine group who delivered my daughter to discuss treatment options for another pregnancy. I was surprised to find that the specialist doesnÃ¢â‚¬â„¢t feel that heparin, aspirin or even increased Folic Acid are necessary as long as my fasting homocysteine levels are normal prior to conception and during my first trimester. I at least thought they would recommend 4 or 5mg of Folic Acid.
With my first pregnancy I faithfully took a PNV several moths before conceiving, during pregnancy and for at least a year after birth since I was breast-feeding. I have no idea what my homocysteine levels were when I developed complications but several months after delivery my levels were within normal limits. I am a bit concerned about the lack of treatment recommended for a future pregnancy because the 1mg of Folic Acid that was in the PNV I was taking with my pregnancy obviously wasnÃ¢â‚¬â„¢t enough.
I am considering seeking a second opinion but I have heard that newer research is suggesting these Heparin/aspirin therapy could cause more harm than good.
I wanted to know what your thoughts are regarding treatment.
Should I be on Heparin and Aspiring therapy?
What amount of Folic Acid, B12, B6 do you recommend?
If my Homocysteine levels are normal my first trimester would they most likey remain normal?