Simple prepregnant prediction rule for recurrent

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darateacher
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Re : Simple prepregnant prediction rule for recurrent

Postby darateacher » Mon Jan 26, 2009 12:58 am

My cholesterol ratio has been a bit off for a while due to family inheritance. However, since I am a runner when I'm not pg, my HDL is usually far above 40, where the docs like to see it. I think at last check up in '05-06, I was at 54, or something like that.

kara
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Re : Simple prepregnant prediction rule for recurrent

Postby kara » Thu Jan 22, 2009 04:17 pm

hmm...I have high LDL and high HDL. My doc is ok with my cholesterol because the good is high, even thought he bad is high. Which seems a bit bizarre to me, but then again I was probably the only, healthy, active, fit 12 year old with high cholesterol. But then again I gotta bunch of other underlying disorders, so it probalby doesn't pertain to me anyway.

alviarin
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Re : Simple prepregnant prediction rule for recurrent

Postby alviarin » Thu Jan 22, 2009 03:50 pm

Can I borrow those weights?

My "good" cholesterol is low too, darn it.

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caryn
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Re : Simple prepregnant prediction rule for recurrent

Postby caryn » Thu Jan 22, 2009 01:20 pm

Oh, I'm just ranting. They've developed an algorithm that will let them plug in your personal variables -- like your age, your gestational age at onset, your HDL levels, your 24-hour proteinuria -- and then it will tell you if you're at low risk of recurrence regardless of the fact that you've got a history of PE.

In other words, it picks out the subset of women who've had it, and who *probably* won't get it again.

And the fact that they mentioned HDL so prominently means that it was kind of important. There's some reason to think that the risk for later cardiovascular disease onset is related to low HDL, too.

IIRC, you can raise HDL with niacin and hard exercise. (...Caryn goes off to pick up the weights. Again.)

jgrumet
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Re : Simple prepregnant prediction rule for recurrent

Postby jgrumet » Thu Jan 22, 2009 01:32 am

Wow, I didn't understand any of that

kara
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Re : Simple prepregnant prediction rule for recurrent

Postby kara » Wed Jan 21, 2009 03:58 pm

Can you dumb that down a bit, Caryn? Did they weed out those with clotting, renal and other disorders? And where does the HDL come in?

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caryn
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Simple prepregnant prediction rule for recurrent

Postby caryn » Wed Jan 21, 2009 03:01 pm

...Early-onset preeclampsia and/or HELLP recurred in 16 (9%) of 186 next pregnancies. The prediction model included high-density lipoprotein (mmol/L) and 24-hour urinary total protein excretion (mg/mmol creatinine). The receiver operating characteristic area was 0.77 (95% confidence interval: 0.68-0.87). Predictive sensitivity and specificity were 94% (69%-99%) and 53% (45%-60%), respectively. Nearly 50% of the women could be classified as having <1% risk of recurrent early-onset disease...

http://www.ncbi.nlm.nih.gov/pubmed/19144890

Great. My HDL is low.

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