by caryn (10146 Posts), Thu Jan 22, 2009 01:36 pm
...Of the 235 women enrolled in the trial, 118 were randomized to receive CoQ10 and 117 received a placebo. A total of 197 (83.8%) women were followed-up. The overall rate of pre-eclampsia was 20% (n=47). Thirty women (25.6%) in the placebo group developed pre-eclampsia compared with 17 women (14.4%) in the CoQ10 group, and this reduction was significant (P=0.035) (relative risk [RR] 0.56; 95% confidence interval [CI], 0.33-0.96)...
Y'all know what I'm going to say: ask your MFMs before you supplement this. It's a smallish study from Ecuador, published in a decent journal, and we will need further testing to confirm or deny the value of this intervention.
One thing that pops out at me is that they state they enrolled women "at increased risk" of PE and that then they had a 20% preeclampsia rate. It would be very useful to sort out *which* women benefited from this -- just the chronics? just the autoimmune cases? just the thrombophiliacs? -- and whether or not it made outcomes for people with different underlying disorders *worse*.
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