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H19 Gene Imprinting in Normal Pregnancy and PE

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H19 Gene Imprinting in Normal Pregnancy and PE

Postby caryn » Mon Apr 06, 2009 01:51 pm

by caryn (10111 Posts), Mon Apr 06, 2009 01:51 pm

...About 40-46% of subjects at varying stages of normal pregnancy showed the H19 heterozygote, and 24 out of 87 (27.59%) heterozygous cases were at 5-9 weeks of gestation, but no single one in other stages displayed biallelic expression of the H19 gene. (2) Thirteen out of 30 pre-eclampsia patients were H19 heterozygous and six of these showed the biallelic expression of the H19 gene (loss of imprinting). (3) The pre-eclampsia patients with the biallelic expression of H19 tended to have severer hypertension although their H19 RNA transcription level was similar to that in those with monoallelic expression...

http://www.ncbi.nlm.nih.gov/pubmed/19342096

So what this says is that sometimes, this one gene gets switched on. And in 6 of the 30 preeclamptics who were carrying two copies of it, they had preeclampsia even though some other parts of the way that gene was expressed were similar to the people with one copy of it. :-) It is very, very hard to pick out genetic associations with this thing.

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