Overrepresentation of BclI polymorphism

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Overrepresentation of BclI polymorphism

Postby caryn » Mon Apr 06, 2009 02:25 pm

...There were no significant differences in carrier and allelic frequencies of the N363S and ER22/23EK polymorphisms between healthy pregnant women and those with severe preeclampsia. However, the allelic and carrier frequencies of the BclI polymorphism were significantly higher in women with HELLP syndrome compared to healthy pregnant women (p=0.004; Odds ratio, 2.89) and to those with severe preeclampsia (p=0.013; Odds ratio, 2.56)...

http://www.ncbi.nlm.nih.gov/pubmed/19336230

So women with BclI are about two and a half times more likely to get HELLP than others, which bumps their odds to what, 1.5%? (HELLP is around .5% of women, roughly.) We couldn't screen for HELLP very effectively with those odds.

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