Chymase mediates endothelial activation

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Chymase mediates endothelial activation

Postby caryn » Sun Jun 07, 2009 00:37 am

...These observations suggest that placental-derived CLP/chymase is responsible for inducing endothelial inflammatory phenotypic changes possibly by upregulation of cell adhesion molecule expressions, activation of cellular protease, and induction of ERK phosphorylation. We speculate that activation of endothelial CLP/chymase may directly relate to the increased inflammatory phenotypic changes in the vascular system in women with PE...

So, they've taken plasma from PE patients, pulled out this one particular protein, and put it into a dish of cultured endothelial cells. And what it does is switch on a whole *bunch* of stuff, including some stuff that makes ya clot ("cell adhesion molecule expressions".) This sort of research may, in the long run, give us some idea of where to intervene in the preeclampsia cascade...


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