APS pregnancy-outcome review

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APS pregnancy-outcome review

Postby caryn » Mon Jun 29, 2009 04:15 am

...False-positive IgM for toxoplasmosis, others, rubella, cytomegalovirus, herpes viruses (TORCH) complex is associated to a worse pregnancy outcome because it reflects a dysregulation of the immune system which may amplify placental autoimmune damage. Moreover low levels of complement components are related to an increased incidence of obstetrical complications, suggesting that placental deposition of immune complexes and activation of complement cascade may contribute to placental failure APS related. The abnormal uterine Doppler velocimetry, false-positive TORCH IgM and low levels of complement components can be considered prognostic indexes of poor pregnancy outcome in APS...

http://www.ncbi.nlm.nih.gov/pubmed/19557318

So if everything goes kablooey, the outcome for APS patients is not so good, because your immune system is all pissed off. We knew this, but it's interesting to see it laid out so specifically.

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