Placental dysferlin expression is reduced in sPE

[caryn]

Placental DYSF expression was 57% lower at the mRNA level (p=0.03) and 38% lower at the protein level (p=0.026) in severe PE as compared to normotensive subjects. There were no differences in placental MYOF protein or mRNA expression between these groups. No appreciable changes in the distribution of DYSF or MYOF within placental villi was observed in PE relative to control specimens. We conclude that DYSF expression is reduced in severe PE relative to gestational age-matched controls. As DYSF has a role in membrane repair, these data suggest a role for DYSF in the stability of the apical STB plasma membrane and may account, at least in part, for the increased shedding of microparticles from this membrane in PE...

http://www.ncbi.nlm.nih.gov/pubmed/19545895

Ah, so the placenta is busted in a particular way that perhaps makes it more likely that bits of the placenta get into the maternal bloodstream, thus annoying our immune systems...


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