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Role of EG-VEGF in human placentation

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Role of EG-VEGF in human placentation

Postby caryn » Thu Jul 16, 2009 09:42 pm

by caryn (10131 Posts), Thu Jul 16, 2009 09:42 pm

...These findings identify EG-VEGF as a novel paracrine regulator of trophoblast invasion. We speculate that a failure to correctly down-regulate placental expression of EG-VEGF at the end of the first trimester of pregnancy might lead to PE...

http://www.ncbi.nlm.nih.gov/pubmed/19602057

So, in cell cultures, using a particular inhibitor reversed the biochemical changes in the preeclampsia cells... which suggests a possible role for the chemical it's inhibiting in mucking up the implantation of the placenta. Which might lead us in the direction of tests, or therapies, in the long run.

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