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Maternal anti-protein Z antibodies

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Maternal anti-protein Z antibodies

Postby caryn » Thu Jul 16, 2009 09:49 pm

by caryn (10124 Posts), Thu Jul 16, 2009 09:49 pm

Patients with SGA neonates have a higher median plasma concentration of IgG APZ-AB than normal pregnant women, or patients with PE or FD; and (2) maternal plasma IgM APZ-AB concentration >90th percentile was associated with vascular placental lesions in patients with PE, but not in those with an SGA neonate, suggesting that in a subset of patients, these antibodies can be associated with abnormal placentation and pregnancy complications...

http://www.ncbi.nlm.nih.gov/pubmed/19591071

So this is a marker that breaks in a differential way -- a higher level than normal means *either* an SGA baby, *or* PE with placental lesions but a normally sized baby. That's interesting, because it means in PE with SGA the SGA is developing through a different mechanism. There's more than one biochemical way for this protein to act in a pregnancy, depending on the particular underlying susceptibility of a particular case.

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