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Analysis of Nitric Oxide Metabolism

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Analysis of Nitric Oxide Metabolism

Postby caryn » Fri Oct 02, 2009 08:02 pm

by caryn (10124 Posts), Fri Oct 02, 2009 08:02 pm

Pre-eclamptic and control placentas did not show any significant differences in their NO metabolite levels or their NOS expression levels as measured by quantitative RT-PCR. In addition, we did not find any association between pre-eclampsia and the occurrence of the Glu298Asp amino acid substitution in the NOS gene. In contrast, high maternal circulating NO metabolites were evident in severe pre-eclampsia (p < 0.0001). Although a positive correlation between circulating NO metabolites and blood pressure was not observed, uterine artery resistance measured by ultrasound was found to positively correlate with the maternal NO levels.

http://www.ncbi.nlm.nih.gov/pubmed/19776611

What this means is that one thing we thought might be causal -- there is a whole metabolic pathway switched on HIGH in preeclamptics -- probably isn't. Instead, it's probably a symptom of the disease, and is correlated to preeclampsia rather than causing it.

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