Hypoxia upregulates GCM1 in human placenta explant

The Preeclampsia Foundation does not necessarily endorse any research or news found in this forum, we just want to share what is out there. Please use your own discretion to evaluate any information you find here.
User avatar
Forum Moderator
Posts: 10203
Joined: Fri Jun 25, 2004 06:36 am

Hypoxia upregulates GCM1 in human placenta explant

Postby caryn » Mon Oct 26, 2009 07:12 pm

This study has shown that acute hypoxia increases GCM-1 protein in villous explants. The experiments with purified trophoblast do not support a role for hypoxia increasing GCM-1 in these cells under the conditions used. The present findings are in keeping with the complex effects of oxygen depending on the conditions used. The hypoxic effects on GCM1 warrant further investigation...


This is interesting, mostly because it points up why studying just trophoblastic cells doesn't give us information that's as relevant. Instead we need to study *placental* cells, ones that result developmentally from the interaction between the uterine cells and the trophoblasts. So we used to think probably GCM-1 didn't upregulate under hypoxic conditions, because when we looked at just trophoblasts it didn't, but if we look at placental explant, it does.

Information provided on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disorder, or prescribing any medication. The Preeclampsia Foundation presents all data as is, without any warranty of any kind, express or implied, and is not liable for its accuracy, for mistakes or omissions of any kind, nor for any loss or damage caused by a user's reliance on information obtained on the site. Professional opinions on this condition vary greatly. The Preeclampsia Foundation endorses no one course of treatment or "cure".

Return to “Announcements and Preeclampsia in the News”

Who is online

Users browsing this forum: No registered users and 3 guests