sildenafil for the treatment of preeclampsia.

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Re : sildenafil for the treatment of preeclampsia.

Postby blythe » Mon Oct 26, 2009 08:42 pm

Darn it, that did sound hopeful when I heard about it before.

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sildenafil for the treatment of preeclampsia.

Postby caryn » Mon Oct 26, 2009 07:34 pm

Of 35 women, 17 were allocated to sildenafil and 18 to placebo. There was no difference in time from randomisation to delivery in the two treatment groups, with a median time of 4 days (range 1-15) in the sildenafil group and 4.5 days (range 1-30) in the placebo group. Sildenafil achieved maximum drug concentrations of 48 ng/ml, 88 ng/ml, and 271 ng/ml after 3 days of 20 mg, 40 mg and 80 mg tid, respectively.

Darn it, Viagra doesn't seem to be working for us. The idea was that it was a vasodilator, and might buy enough time for steroids, but it didn't delay delivery in this (very small) study.

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