New Study Heralds Use of Blood Biomarkers to Predi

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New Study Heralds Use of Blood Biomarkers to Predi

Postby caryn » Mon Nov 23, 2009 11:41 am

..."This study represents a very important step forward; for the first time ever, we are presented with the possibility, for clinical use, of a combination of factors to predict early onset preeclampsia with a reasonable degree of accuracy," says Professor Marshall Lindheimer, Professor Emeritus of Medicine and Obstetrics & Gynaecology at the University of Chicago.

Preeclampsia is the leading cause of infant death and the second leading cause of maternal death Around the world. Conservative estimates indicate that preeclampsia is responsible for some 76,000 maternal deaths and more than 500,000 infant deaths every year, according to the Preeclampsia Foundation. Early onset preeclampsia is the most dangerous form of this disease... ... 71377.html

So potentially a decent diagnostic test!

Here's a link to the full text of the study, which reads in part The PlGF/sEng ratio and its delta and slope had an excellent predictive performance for the prediction of early-onset preeclampsia, with very high likelihood ratios for a positive test result and very low likelihood ratios for a negative test result; and (2) Although the positive likelihood ratios are high and the positive predictive values low, the number of patients needed to be closely followed is 4:1 for the PlGF/sEng ratio and 3:1 for the slope of PlGF/sEng...

Delta means "rate of change" so the bigger the change between your levels in early pregnancy and in mid-pregnancy, the more useful this test is. It's got 100% sensitivity and 98-99% specificity, so it does a good job of catching all, and primarily, early-onset preeclamptics who need much closer following and management.

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