Alterations in the Renin-Angiotensin System

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Alterations in the Renin-Angiotensin System

Postby caryn » Mon Dec 21, 2009 09:35 am

...(1) The peripheral RAS is downregulated, and the uteroplacental RAS is upregulated in this rat model of preeclampsia; (2) MBG is involved in the causation of these alterations, and (3) RBG prevents these changes...

http://www.ncbi.nlm.nih.gov/pubmed/20016143

So you can block some of the changes in the kidneys. In rats. :-)

The renin-angiotensin system, which they're abbreviating to RAS here, is a way the kidneys control blood pressure. The kidneys produce renin, which gets converted to angiotensin, which raises blood pressure. In preeclamptics it looks like the placenta is producing chemicals which directly muck about with this system. In this animal model (so cool! we have a working animal model now! yay!) it was possible to *block* one of the chemicals being produced by the placenta, which blocked all the changes it made to the RAS.

So in the very long run, this might turn into some sort of treatment. (Very, very long run. Don't wait to get pregnant in the hopes that this might be effective therapy in the future, because it isn't anywhere near to that well understood -- just because it blocks this particular pathway doesn't mean it will stop PE, which operates along multiple pathways -- or safe for use in humans for that matter.)

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