Free leptin index and PAPP-A: a first tri test

[caryn]

fLI was significantly (p < 0.001) elevated [mean log MoM 0.2165 (SD: 0.2604)] compared to controls [mean log MoM -0.0368 (SD: 0.3132)] and PAPP-A was significantly (p < 0.001) reduced [mean log MoM -0.0133 (SD: 0.2661)] compared to controls [mean log MoM 0.0474 (SD: 0.2521)] in PE pregnancies. There was no correlation between fLI and PAPP-A in control or PE pregnancies. Combined fLI and PAPP-A screening for PE had estimated population detection rates of 22% and 35% for false positives rates of 6% and 12%, respectively.

http://www.ncbi.nlm.nih.gov/pubmed/20013873

Heh. This disease is so weird. These two serum values that are often off in PE -- but that aren't off *together*, that don't vary together -- work pretty well if you combine them for a detection test. Not great, but better than if you measure them alone. But the variables don't move together (they're "not correlated"), and so that's odd. (You'd think they'd go up or down or inversely proportional to each other together, but they don't.)

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