Thyroid Dysfunction and Autoantibodies during Preg
Re : Thyroid Dysfunction and Autoantibodies during Preg
Yeah I think the thing with autoimmune is just as you said many have some sort of varying levels of different types (RA, ANA, Lupus, etc.) but no real problems to warrant further investigation...so it goes along under the radar with minimal levels of the things we know to test for...until one day BAM:) I've had up and down RA levels and up and down TSH levels but never to any "diagnostic" point...what do you do with that except wait...*big sigh*
Re : Thyroid Dysfunction and Autoantibodies during Preg
I suspect that we're talking flipped switches all over the place, you know?
At this point I kind of doubt that we can really pin gestational hypertension on autoimmune disease. More likely both conditions rest on underlying genetic mutations that are normal for humans and that have to do with the arms race of head-through-pelvis. So an autoimmune disease might unmask your risk, but not cause it -- given that so many women with autoimmune diseases don't have problems, this just seems sensible to me -- and same thing with obesity or whatever.
It's just a thing humans have happen. *sigh*
At this point I kind of doubt that we can really pin gestational hypertension on autoimmune disease. More likely both conditions rest on underlying genetic mutations that are normal for humans and that have to do with the arms race of head-through-pelvis. So an autoimmune disease might unmask your risk, but not cause it -- given that so many women with autoimmune diseases don't have problems, this just seems sensible to me -- and same thing with obesity or whatever.
It's just a thing humans have happen. *sigh*
Re : Thyroid Dysfunction and Autoantibodies during Preg
Boy it sounds like PE unmasks a whole bunch of predispositions for diseases, HTN, cardiac, Thyroid, Autoimmune...what else... my undiagnosed acquired (non-autoimmune at this point)hemophilia...geez!
Thyroid Dysfunction and Autoantibodies during Preg
Thyroid dysfunction and antibodies were not associated with pregnancy complications. Overt hypothyroidism was associated with subsequent maternal thyroid disease [hazard ratio (HR) (95% confidence interval), 17.7 (7.8-40.6)] and diabetes [6.0 (2.2-16.4)]. Subclinical hypothyroidism [3.3 (1.6-6.9)], TPO-Ab-positivity [4.2 (2.3-7.4)], and TG-Ab-positivity [3.3 (1.9-6.0)] were also associated with later thyroid disease. No association was found between thyroid dysfunction/antibodies and hypertension or overall mortality...
http://www.ncbi.nlm.nih.gov/pubmed/20080846
This one says, actually, thyroid problems in pregnancy are only predictive of later thyroid problems. So here's more of that correlation/causation problem -- is it that there's subclinical thyroid problems in more PE patients but that it isn't predictive of PE, or what?
Information provided on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disorder, or prescribing any medication. The Preeclampsia Foundation presents all data as is, without any warranty of any kind, express or implied, and is not liable for its accuracy, for mistakes or omissions of any kind, nor for any loss or damage caused by a user's reliance on information obtained on the site. Professional opinions on this condition vary greatly. The Preeclampsia Foundation endorses no one course of treatment or "cure".
http://www.ncbi.nlm.nih.gov/pubmed/20080846
This one says, actually, thyroid problems in pregnancy are only predictive of later thyroid problems. So here's more of that correlation/causation problem -- is it that there's subclinical thyroid problems in more PE patients but that it isn't predictive of PE, or what?
Information provided on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disorder, or prescribing any medication. The Preeclampsia Foundation presents all data as is, without any warranty of any kind, express or implied, and is not liable for its accuracy, for mistakes or omissions of any kind, nor for any loss or damage caused by a user's reliance on information obtained on the site. Professional opinions on this condition vary greatly. The Preeclampsia Foundation endorses no one course of treatment or "cure".
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