Pathogenesis of preeclampsia

The Preeclampsia Foundation does not necessarily endorse any research or news found in this forum, we just want to share what is out there. Please use your own discretion to evaluate any information you find here.
User avatar
Forum Moderator
Posts: 10203
Joined: Fri Jun 25, 2004 06:36 am

Pathogenesis of preeclampsia

Postby caryn » Wed Jan 20, 2010 12:31 am

Placental antiangiogenic factors are upregulated and disrupt the maternal endothelium. This change in the normal angiogenic balance toward an antiangiogenic state can result in hypertension, proteinuria, glomerular endotheliosis, HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome, and cerebral edema-the clinical signs of preeclampsia and eclampsia. The regulation of these antiangiogenic factors in the placenta is unknown.

Just a review paper that says what essentially everyone's saying: now that we know it's caused by the placenta and roughly which molecules to look at, we have a research agenda that might give us tests and interventions in the long run, but at the moment, we are still trying to figure this out because it is evo-devo and extremely hard. On that note, this video tries to explain some of this and makes me giggle.

Information provided on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disorder, or prescribing any medication. The Preeclampsia Foundation presents all data as is, without any warranty of any kind, express or implied, and is not liable for its accuracy, for mistakes or omissions of any kind, nor for any loss or damage caused by a user's reliance on information obtained on the site. Professional opinions on this condition vary greatly. The Preeclampsia Foundation endorses no one course of treatment or "cure".

Return to “Announcements and Preeclampsia in the News”

Who is online

Users browsing this forum: No registered users and 8 guests