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Periodontal disease, oxidative stress, & PE risk

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Periodontal disease, oxidative stress, & PE risk

Postby caryn » Wed Feb 17, 2010 02:20 pm


Women with oxidative stress early in pregnancy, as measured by an 8-isoprostane concentration >/=75th percentile, were at an increased risk for developing preeclampsia. The presence of periodontal disease did not appear to modify this risk.

http://www.ncbi.nlm.nih.gov/pubmed/20151797

So that countermands the previous studies showing a correlation between PE and peridontal disease; it's the higher level of oxidative stress and not the gum disease that's a concern. Not that anyone is healthiest if walking around with gum disease, for an entirely different set of reasons!

(Elevated oxidation is well-recognized as a component of preeclampsia, which is why they looked into antioxidant vitamins as therapy. They don't seem to help, though, so ask your docs before starting any vitamin supplements.)

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Re : Periodontal disease, oxidative stress, & PE risk

Postby l412angel » Wed Feb 17, 2010 03:38 pm

What does oxidative stress mean?
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Re : Periodontal disease, oxidative stress, & PE risk

Postby caryn » Wed Feb 17, 2010 11:02 pm

Honestly, they don't know.

It's elevated in a number of diseases, but treating it with antioxidants (vitamin C and E) doesn't seem to help, either in PE or in other cases. There are probably some situations I'm not remembering where it might be beneficial, but that's always a question for your docs. :)
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