placental tissue factor etc. in sPE

The Preeclampsia Foundation does not necessarily endorse any research or news found in this forum, we just want to share what is out there. Please use your own discretion to evaluate any information you find here.
User avatar
Forum Moderator
Posts: 10203
Joined: Thu Feb 16, 637032 6:26 pm

placental tissue factor etc. in sPE

Postby caryn » Fri Sep 30, 638929 4:30 am

The plasma TF level in the pre-eclampsia group was significantly higher than the control group (p<0.01), and surprisingly, the plasma TFPI-1 and TFPI-2 in the pre-eclampsia group were significantly lower (p<0.01)...

So we are making more tissue factor and have more of it in our bloodstreams, which might be one of the proteins that's making us more likely to clot. We've also got less of the stuff that mops up tissue factor -- the genes to make tissue factor are working over time, and the genes to inhibit it are turned down -- which means something (probably the placenta, DUM DUM DUUUUUM!) has mucked about with the regulatory settings.

I swear *every* soluble factor they measure is off in us.

Information provided on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disorder, or prescribing any medication. The Preeclampsia Foundation presents all data as is, without any warranty of any kind, express or implied, and is not liable for its accuracy, for mistakes or omissions of any kind, nor for any loss or damage caused by a user's reliance on information obtained on the site. Professional opinions on this condition vary greatly. The Preeclampsia Foundation endorses no one course of treatment or "cure".

Return to “Announcements and Preeclampsia in the News”

Who is online

Users browsing this forum: No registered users and 3 guests