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placental tissue factor etc. in sPE

Posted: Sat May 08, 2010 04:22 pm
by caryn
The plasma TF level in the pre-eclampsia group was significantly higher than the control group (p<0.01), and surprisingly, the plasma TFPI-1 and TFPI-2 in the pre-eclampsia group were significantly lower (p<0.01)...

So we are making more tissue factor and have more of it in our bloodstreams, which might be one of the proteins that's making us more likely to clot. We've also got less of the stuff that mops up tissue factor -- the genes to make tissue factor are working over time, and the genes to inhibit it are turned down -- which means something (probably the placenta, DUM DUM DUUUUUM!) has mucked about with the regulatory settings.

I swear *every* soluble factor they measure is off in us.

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