Expression of AT1R, AT2R and AT4R and their roles

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Expression of AT1R, AT2R and AT4R and their roles

Postby caryn » Fri May 14, 2010 11:45 am

Expression of AT4R was increased in term placentae, with a significant reduction in PE placentae. Moreover, culture with AngIV or AngII increased EVT invasion from placental explants, which showed increased trophoblast proliferation and reduced apoptosis.

http://www.ncbi.nlm.nih.gov/pubmed/20304486

So the expression of the placental gene that makes a receptor for angiotensin -- receptors pull ang out of the bloodstream and keep it from raising blood pressure etc. -- is reduced in preeclamptics. For whatever reason, the placenta's turned that off, probably because it wants to raise our blood pressure to pump more blood across the shallow interface.

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