Eculizumab for the treatment of preeclampsia/HELLP syndrome

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Eculizumab for the treatment of preeclampsia/HELLP syndrome

Postby sam10 » Fri Dec 28, 2012 12:59 am

"...patient presenting with severe preeclampsia/HELLP syndrome at 26 weeks gestation that was treated with Eculizumab, a targeted inhibitor of complement protein C5, which resulted in marked clinical improvement and complete normalization of lab parameters. Pregnancy was prolonged 17 days, likely resulting in a reduction of neonatal morbidity with its associated short and long-term health care costs. Successful use of Eculizumab in this case suggests that complement inhi- bition may be an effective treatment strategy for severe preeclampsia/HELLP syndrome."

article in press as: Burwick RM, Feinberg BB, Eculizumab for the treatment of preeclampsia/HELLP syndrome, Placenta (2012), http://dx.doi.org/10.1016/j.placenta.2012.11.014
~Julija (40)
MC 3/2009 and 3/2011
Henry (1/1/2010-1/7/2010) - forever loved and missed; severe PE with Hellp; partial placental abruption, classical c-section at 25.6 weeks
Matilda (Nov. 2012, born at 35.4 weeks) - severe PE


Our pain has been put into words, placed into empty cradles, to remember that all our babies lived, that they mattered and always will. - Field of Cradles http://www.fieldofcradles.org/
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Re: Eculizumab for the treatment of preeclampsia/HELLP syndr

Postby rosalinda » Fri Dec 28, 2012 07:07 pm

Caryn,

Is this available in the US? Have you heard of this before?
-Elissa, January 2007: stillborn at 25 weeks, severe PE, IUGR, reverse-end diastolic flow
- Chronic hypertension as of November 2007
-missed miscarriage Feb 2009
- Ismael Jaden, June 2010, 36 wks, oligohydramnios & rising BP's, my wonderful little man & the love of my life
- Janelle, September 2011, 24wks, 3days. complete placental abruption & DIC, stillborn
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Re: Eculizumab for the treatment of preeclampsia/HELLP syndr

Postby sam10 » Fri Dec 28, 2012 08:13 pm

The treatment described was done in the US. I am not sure if it is currently available, but I can try to find out.
~Julija (40)
MC 3/2009 and 3/2011
Henry (1/1/2010-1/7/2010) - forever loved and missed; severe PE with Hellp; partial placental abruption, classical c-section at 25.6 weeks
Matilda (Nov. 2012, born at 35.4 weeks) - severe PE


Our pain has been put into words, placed into empty cradles, to remember that all our babies lived, that they mattered and always will. - Field of Cradles http://www.fieldofcradles.org/
sam10
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Re: Eculizumab for the treatment of preeclampsia/HELLP syndr

Postby caryn » Tue Jan 15, 2013 06:54 pm

This was a case study in Boston, but I'm not sure how the use got approved or what the guidelines/ timeline would be for it to be used in HELLP patients. I suspect that it was used under "compassionate care" guidelines - which is essentially where they decide we're so sick that there's no further harm from throwing the kitchen sink at us in quiet desperation!

Here's another article: http://www.medscape.com/viewarticle/739513

As I understand it, this would be for the subset of women with lupus or APS who have a particular mutation in a gene that codes for a complement factor. That means a subset of us who get PE?HELLP because of genetic autoimmune conditions. "Complement factors" are responsible for the innate immune response to foreign proteins: http://en.wikipedia.org/wiki/Complement_system

I'll keep an eye out and see what else this research stream produces!
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies? Lectures from researchers?
A chance to participate in research? For us on Facebook or Twitter?

Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy
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