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Cellular Fetal Microchimerism in Preeclampsia

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Cellular Fetal Microchimerism in Preeclampsia

Postby caryn » Wed Oct 23, 2013 09:25 am

by caryn (10124 Posts), Wed Oct 23, 2013 09:25 am

"We conclude that women with preeclampsia harbor cellular fetal microchimerism more commonly and at higher concentrations compared with women with uncomplicated pregnancy. The functional capacity and phenotype of these fetal cells are not yet known."

http://www.ncbi.nlm.nih.gov/pubmed/24101661

So more of the fetal cells get into our circulation than in normal pregnancy, and we don't know why they're there, or what they're doing. They might be affecting our metabolism, or triggering a stronger immune reaction, or repairing damage from pregnancy, or mucking with our thyroids, or any number of other possibilities.
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DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy
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Re: Cellular Fetal Microchimerism in Preeclampsia

Postby angieb » Wed Oct 23, 2013 09:01 pm

by angieb (1192 Posts), Wed Oct 23, 2013 09:01 pm

Interesting.

Would these be the same fetal cells that are tested from the mother's blood in the newest (Maternti21 / Harmony) genetic tests? Would it throw off those results?
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Re: Cellular Fetal Microchimerism in Preeclampsia

Postby caryn » Thu Oct 24, 2013 09:42 am

by caryn (10124 Posts), Thu Oct 24, 2013 09:42 am

Yes, and no. They don't do a quantitative count. But this suggests that if they *did*, those tests might have some utility as screening tests for preeclampsia. Probably a pretty low sensitivity though, because not every member of the population of preeclamptics showed an increase in fetal microchimerism, even if the population as a whole showed a very large increase.
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies? Lectures from researchers?
A chance to participate in research? For us on Facebook or Twitter?

Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy
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Re: Cellular Fetal Microchimerism in Preeclampsia

Postby alviarin » Mon Oct 28, 2013 12:03 am

by alviarin (1645 Posts), Mon Oct 28, 2013 12:03 am

Could this increase be caused by preeclampsia? (Since we have leakier blood vessels, and higher pressures....)

Or maybe this is co-incidental? Maybe more fetal DNA in circulation equals more autoimmune disorders, which tend to be risk factors for preeclampsia. Just wondering...
Hypothyroid mom to Connor and Claire
(severe pre-e at 38 weeks & "mild" pre-e at 37 weeks)
& baby Annabelle
(chronic HTN & GD, superimposed pre-e @34 weeks, induction @37 weeks)
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Re: Cellular Fetal Microchimerism in Preeclampsia

Postby caryn » Thu Oct 31, 2013 12:57 am

by caryn (10124 Posts), Thu Oct 31, 2013 12:57 am

It has to do with the initial invasion not being "seen" properly by our immune systems, I think. The leaky vasculature should just leak into the interstitial spaces between the cell walls, not into the maternal bloodstream.

The autoimmune disorders are a cause/effect problem. Do we have autoimmune disorders because we have odd immune systems which predispose us to preeclampsia? Does exposure to foreign human proteins because of odd invasion trigger autoimmune disease?
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies? Lectures from researchers?
A chance to participate in research? For us on Facebook or Twitter?

Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy
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Re: Cellular Fetal Microchimerism in Preeclampsia

Postby alviarin » Wed Nov 06, 2013 12:02 am

by alviarin (1645 Posts), Wed Nov 06, 2013 12:02 am

Makes sense, thanks!
Hypothyroid mom to Connor and Claire
(severe pre-e at 38 weeks & "mild" pre-e at 37 weeks)
& baby Annabelle
(chronic HTN & GD, superimposed pre-e @34 weeks, induction @37 weeks)
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Re: Cellular Fetal Microchimerism in Preeclampsia

Postby chal4oye » Fri Jan 31, 2014 04:54 am

by chal4oye (1 Posts), Fri Jan 31, 2014 04:54 am

Or maybe this is co-incidental? Maybe more fetal DNA in circulation equals more autoimmune disorders, which tend to be risk factors for preeclampsia. Just wondering...
http://www.mybraindumps.net/
http://www.cisco.com/
http://www.mybraindumps.net/CCNA-guide.html
http://www.harvard.edu/
http://en.wikipedia.org/wiki/Cisco_Systems
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