Vasopressin: The Missing Link for Preeclampsia?

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caryn
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Vasopressin: The Missing Link for Preeclampsia?

Postby caryn » Fri Apr 03, 2015 01:11 am

"Various lines of evidence support a "tissue rejection" type reaction toward the placenta as the primary initiating event in the development of preeclampsia, followed by a complex interplay among immune, vascular, renal, and angiogenic mechanisms that have been implicated in the pathogenesis of preeclampsia beginning around the end of the first trimester. Critically, it remains unclear what mechanism links the initiating event and these pathogenic mechanisms."

http://www.ncbi.nlm.nih.gov/pubmed/25810383

So, in mice, injecting arginine vasopressin creates preeclampsia symptoms - which might mean it's one of the triggers of preeclampsia symptoms in humans. If we could block the activity of triggers of the symptoms, at least some pregnancies could be sustained for longer. Blocking these triggers wouldn't implant the placenta better, so there are cases that wouldn't be helped by this, but anything that allows docs to block or delay the onset of symptoms would likely allow many preeclamptic pregnancies to last longer. I'll take "days not in NICU" and "time for steroids", so I hope this is supported in followup research!
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies?
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Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy

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