by riehlism (655 Posts), Thu Mar 10, 2011 06:27 pm
They typically do pathology reports on the placenta looking for microclots, which corroborates the preeclampsia dx. In preeclampsia is definitely a fight between the placenta and the mom. One of the more popular theories is that it is due to poor implantation. The code for implantation is found in Dad's sperm. Sometimes poor implantation takes place because the burrowing of the embryo is too shallow...perhaps the blood-rich lining of the endometrium is too thick or too dense for the embryo to burrow through.
It's thought that in the first trimester the blood vessels and in the umbilical cord distend and grow. In a case where preeclampsia may be present, bloodflow between mom and placenta is restricted (maybe due to poor dilation). So the placenta sends off these hormones because it's essentially "hungry for blood" thus raising mom's BP, etc. This creates a scenario of an apparent immune response--hence the baby aspirin so this doesn't start in the first place.
Baby aspirin is far too small a dosage to break down a clot, but it does keep things more fluid. A recent study published by OBGYN shows a meta-analysis of various research studies done in the past. It was promising study not just because it shows that those who take LDA have more favorable subsequent pregnancies, but it also helped to support the above theory I described in terms of its pathophysiology. Oh, and another tidbit I've shared before on this site is that preeclampsia used to be called toxemia. Tox for toxic or bad, emia for blood. But probably because of the eclamptic seizures women have they decided to call it preeclampsia instead of toxemia. All for the best since it's not 100% proven to be a pure blood disorder. Like many of us, we're fine in that department.
So while there are a slew of possible factors, the information in my previous post was stemming from that recent study. I guess we'll see what they come up with tomorrow.
Jasmin: Severe PE/HELLP and delivered at 24+6 & PCOS (29) Hubby Bubby, Frank (29) Baby Blue
stopped in to say hello and goodbye on 6/3/10Baby Lucas was born on 10/13/11, PE and HELLP-free! Thank you baby aspirin and Lovenoxhttp://www.ehd.org/pregnancy-calendar.php?id=18192