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Is there any connection between celiac disease and hypertensive disorders of pregnancy? Is it perhaps an underlying inflammatory disorder, or might it cause a nutritional deficiency which would result in PE?
Celiac disease, also called Sprue is associated with confounders, including other immunological problems, vitamin deficiencies etc., and may also be underdiagnosed (a small % of ÃƒÂ¢Ã¢â€šÂ¬Ã…â€œnormalÃƒÂ¢Ã¢â€šÂ¬Ã‚Â women harboring gluten antibodies or might show pathology if their gut mucosa were to be biopsied). Even adding these, though, would never create a population large enough for anyone to have studied the question meaningfully. Thus, I wager that any opinions a literature search might reveal would be anecdotal, as well as in the gastroenterology literature whose authors might not be exact or knowledgeable about the diagnosis of preeclampsia. Of interest, the disease seems not to have been mentioned in ChesleyÃƒÂ¢Ã¢â€šÂ¬Ã¢â€žÂ¢s classic text devoted to preeclampsia, nor did the individual authoring the chapter on gastroenterology in my medical problems text mention any associations. The disease, in part to malnutrition, is known to be associated with fertility problems and poor fetal growth.
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