stress upregulates cytokines, raises PE risk?

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stress upregulates cytokines, raises PE risk?

Postby expert@preeclampsia.org » Wed Apr 18, 2007 01:50 pm

Would anyone be willing to comment on this study?

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17029703&query_hl=1&itool=pubmed_docsum
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Re : stress upregulates cytokines, raises PE risk?

Postby expert@preeclampsia.org » Wed Apr 18, 2007 01:51 pm

On my way out of town and can't take time to polish, etc....stress doesn't cause preeclampsia, but it can raise a person's blood pressure. Blood pressure is one parameter of preeclampsia. Will be interesting to study patients with stress once we have a good biomarker for the disease rather than a sign.
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Re : stress upregulates cytokines, raises PE risk?

Postby expert@preeclampsia.org » Wed Apr 18, 2007 01:51 pm

Stress is real and can lead to disease. It increases cytokines, oxidative stress, catecholamines and glucocorticoids. In general the most telling forms of stress are chronic, not acute but you can demonstrate increases in strokes and heart attacks after earthquakes etc.
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Re : stress upregulates cytokines, raises PE risk?

Postby expert@preeclampsia.org » Wed Apr 18, 2007 01:51 pm

I agree with xxx. I think stress can cause a process to reach a tipping point
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Re : stress upregulates cytokines, raises PE risk?

Postby expert@preeclampsia.org » Wed Apr 18, 2007 01:52 pm

I do not think there is much doubt that stress can alter markers of inflammatory activation. In baboons, stress associated with animal transport results in a very high rate of pregnancy loss.

That said, we should be careful in attributing adverse pregnancy outcomes due to preeclampsia in human pregnancy to maternal stress without clear data. The association opens the door for women to blame themselves for having too much stress in their lives and therefore being responsible for their bad outcome. A number of us have tried to find cytokine markers that would serve as markers or predictors of preeclampsia - without much success. There are may be some statistical associations - but the overlap in data point is usually very large.

The abstract is very general in its content. I would certainly want to see more about study design and the robustness of the findings.
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Re : stress upregulates cytokines, raises PE risk?

Postby expert@preeclampsia.org » Wed Apr 18, 2007 01:52 pm

REPLYING FROM W.H.O. WITH LITTLE ACCESS TO E MAIL A FRENCH KEYBOARD IN THE HOTEL nor to article

Tend to agree with xxx to be cautious here. MORE IMPORTANT DIFFICULT TO TALK PREECLAMPLSIA FROM A N ARTICLE THAT FOCUSES BUT ON A SURRUGATE MARKER FOR THE DISEASE
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Re : stress upregulates cytokines, raises PE risk?

Postby expert@preeclampsia.org » Wed Apr 18, 2007 01:53 pm

Agree with xxx. Although a reasonable idea and worth pursuing as a topic for study there is little available data. This is an area for study rather than something to worry women or make them feel guilty about. I think the abstract only rasies the possibility that his might be relevant.
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