by email@example.com (322 Posts), Sat Feb 09, 2008 11:38 pm
The answer is yes there can be preeclampsia and its progression to severe complications before 20 weeks. Some of these cases are associated with hytadiform disease (mole), and Trisomy 13, both of which result in raised levels of angiogenic factors. However it is also observed in women without these rare syndromes but often those destined to chronic hypertension later in life. As said it is quite unusual, but Baha Sibai described a group of these patients years ago. There is also a JAMA case report.( Lindheimer MD, Spargo BH, Katz AI: Eclampsia during the 16th gestational week. JAMA 230:1006-8, 1974).
Editor's note: there is also a recent discussion of maternal deaths here: http://www.preeclampsia.org/forum/viewtopic.php?t=21361