Endometriosis prior to conception does not increase womenÃ¢â‚¬â„¢s risk of pre-eclampsia but instead protects against it, suggest experts.
Few studies have looked at the effect endometriosis has on women in late pregnancy. Ivo Brosens and colleagues therefore compared the number of pregnancy complications in 245 women with endometriosis-associated infertility with those in 274 healthy control women.
They found that fewer women with endometriosis suffered from pre-eclampsia, at 0.8 percent, than healthy women controls, at 5.8 percent. The odds of developing pre-eclampsia were 5.67 times higher in women from the control group than in pregnancies following endometriosis-associated infertility.
The authors argue that this may reflect Ã¢â‚¬Å“increased local expression of angiogenic factors and enhanced endometrial vascular perfusion at the time of implantation in women with endometriosis.Ã¢â‚¬Â
They conclude: Ã¢â‚¬Å“Although this explanation remains speculative, our findings do emphasize the importance of the endometrial mileu at the time of conception in determining pregnancy outcome.Ã¢â‚¬Â
Source: Human Reproduction 2007; Advance online publication / Medwire News