Originally posted by Caryn
Theoretically, let's say that you can keep the mother's bp from rising with a drug that's safe for pregnancy that exploits this pathway. Isn't that possibly bad, because the placenta is raising the mother's blood pressure *on purpose* to pump more blood across the interface to the fetus? Isn't the blood pressure increase *adaptive* in a lot of normal pregnancies? I mean, the objections to lowering bp via meds are still in play if this pathway becomes targetable -- the ones that point out how IUGR and compromised blood flow and bp meds don't play together well! This wouldn't solve the problem of a shallowly implanted placenta, so while I can imagine it being helpful for a subset of chronics... I can also imagine it being unhelpful for many other PE patients.
As is often the case, this is highly preliminary stuff. Very interesting highly preliminary stuff. :)
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