sEng and sFlt1 serum concentrations were higher in women with subsequent preeclampsia than in controls (mean +/- SD, sEng: 5.57 +/- 1.18 ng/mL vs 5.02 +/- 1.01 ng/mL, P = .009; sFlt1: 1764 +/- 757 pg/mL vs 1537 +/- 812 pg/mL, P = .036). Sensitivities and specificities for predicting preeclampsia were 63% and 57% for sEng and 64% and 56% for sFlt1, respectively. When sEng and inhibin A were combined, the sensitivity increased to 68%, whereas the specificity was 61%...
This means that even though we know sEng and sFlt-1 are definitely preeclampsia factors, and even though they are elevated in women who develop preeclampsia, measuring them directly doesn't give us a good screening test.
Sensitivity is ability to pick up *all* the preeclamptics, and specificity is ability to pick up *only* the preeclamptics. Usually in a screening test they'll make sacrifices in specificity to improve sensitivity, because it is better not to miss sick people.
These numbers are just examples, but it often comes down to two choices:
1) monitor 40 women closely for preeclampsia even though 29 of them don't get it to avoid failing to catch one (high sensitivity, low specificity)
2) monitor 10 women closely for preeclampsia and miss one woman who does go on to develop it but whom your screening test missed (high specificity, low sensitivity)
But the values aren't really high enough here to make a good screening test. So they're looking for other markers they could measure at the same time that would improve sensitivity and specificity. Adding inhibin A makes the test both more sensitive and more specific, but not enough of either to make the screening test very good. (Coupling these tests to a uterine artery Doppler also helps.)
Information provided on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disorder, or prescribing any medication. The Preeclampsia Foundation presents all data as is, without any warranty of any kind, express or implied, and is not liable for its accuracy, for mistakes or omissions of any kind, nor for any loss or damage caused by a user's reliance on information obtained on the site. Professional opinions on this condition vary greatly. The Preeclampsia Foundation endorses no one course of treatment or "cure".
The Preeclampsia Foundation does not necessarily endorse any research or news found in this forum, we just want to share what is out there. Please use your own discretion to evaluate any information you find here.
1 post • Page 1 of 1
Users browsing this forum: No registered users and 3 guests