Post Reply FAQ Members Login

Gestational hypertension as a subclinical preeclampsia

The Preeclampsia Foundation does not necessarily endorse any research or news found in this forum, we just want to share what is out there. Please use your own discretion to evaluate any information you find here.

Gestational hypertension as a subclinical preeclampsia

Postby caryn » Sun Nov 07, 2010 01:11 am

by caryn (10111 Posts), Sun Nov 07, 2010 01:11 am

"...the levels of sFlt-1/PlGF ratio and sEng in women with GH were lower than in those with h-PE and with si-PE; however, the majority of women with GH showed abnormal increases of both sFlt-1/PlGF ratio and sEng, suggesting that GH may be a subclinical PE in view of serum levels of angiogenesis-related factors..."

http://www.ncbi.nlm.nih.gov/pubmed/21048778

So this has been an ongoing debate! Is there such a thing as "just" a little hypertension at the end of pregnancy? Is it even maybe adaptive -- does it lead to overall better outcomes, and how do you decide which outcomes are better, anyway?

This study does at least confirm that women with raised blood pressure at the end of pregnancy do often have higher levels of the soluble factors linked to preeclampsia symptoms than women who do not see those increases in their blood pressure. The same biochemical stuff is going on, just more mildly. That might help explain why the HYPITAT trial showed a benefit to women with gestational hypertension with induction at 37 weeks, though.
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies? Lectures from researchers?
A chance to participate in research? For us on Facebook or Twitter?

Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy
User avatar
caryn
Forum Moderator
 
Posts: 10111
Joined: Fri Jun 25, 2004 06:36 am

Re: Gestational hypertension as a subclinical preeclampsia

Postby yommytec » Thu Oct 27, 2011 09:39 am

by yommytec (1 Posts), Thu Oct 27, 2011 09:39 am

Does HYPITAT really works or just want of those that are been promoted to scam people?
yommytec
Registered User
 
Posts: 1
Joined: Thu Oct 27, 2011 01:47 pm

Re: Gestational hypertension as a subclinical preeclampsia

Postby blythe » Thu Oct 27, 2011 07:23 pm

by blythe (3060 Posts), Thu Oct 27, 2011 07:23 pm

Yommytec, I'm not sure what you are asking. HYPITAT stands for "Hypertension and Pre-eclapmsia Intervention Trial At Term".

Here is a link to the initial results
http://www.studies-obsgyn.nl/home/page.asp?page_id=357

and here is a link to the study published in the Lancet
http://www.thelancet.com/journals/lance ... 40-6736(09)60736-4/abstract

The study authors found that for hypertensive issues at term, inducing at 37 weeks - with either hypertension alone or pre-eclampsia - resulted in fewer maternal complications, fewer c-sections, and no difference in outcomes for babies (verses letting pregnancy progress and inducing when the disease worsened).

As always, ask your doctor how this study applies to your individual case, there may be reasons your treatment is different.
Heather, mom to
#1 7-18-03 - 5#8oz 37 weeks PE/PIH
#2 8-11-06 - 6#14oz 37 weeks PE/PIH
#3 9-10-09 - 5#10oz 37 weeks PE/PIH
blythe
Registered User
 
Posts: 3060
Joined: Sun Mar 21, 2004 10:24 am


Return to Announcements and Preeclampsia in the News

Who is online

Users browsing this forum: No registered users and 2 guests

cron