Is this the pathophysiology of preeclampsia?

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rodin
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Joined: Sat Dec 17, 2011 7:51 am

Re: Is this the pathophysiology of preeclampsia?

Postby rodin » Sun Dec 18, 2011 12:44 am

I agree that this is still a hypothesis, which has not yet been peer reviewed and certainly should not be automatically accepted as correct.
However I find it is a logically sound new hypothesis. It is different from any current hypothesis on the pathophysiology of preeclampsia, but this isn't an argument against it. If you automatically assume a new hypothesis to be wrong, we would still think all stomach ulcers are caused by stress instead of H. pylori. We might even think the earth is flat...

blythe
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Joined: Sun Mar 21, 2004 10:24 am

Re: Is this the pathophysiology of preeclampsia?

Postby blythe » Sat Dec 17, 2011 02:00 pm

Interesting article! I don't understand the physiology as well as some, but I don't think the author's hypothesis matches with the current research. Note also that no actual research has been done on positioning, and especially note at the bottom that this article has not been peer reviewed.

Avoiding sleeping flat on your back and sleeping on your left side as much as possible is already common advice in pregnancy
http://www.babycenter.com/404_whats-the ... cy_7608.bc
so my completely not-a-doc guess is that the author's hypothesis is probably incorrect - or at least incomplete.

I don't mean to be so negative ;) , this is an interesting article, I just have read a lot more articles that have different conclusions and have more research support! We love reading around here! If you'd like to read more about the biology of preeclampsia I'd recommend starting with

this thread:
http://www.preeclampsia.org/forum/viewt ... 12&t=16607
the articles in Caryn's profile:
http://www.preeclampsia.org/forum/membe ... ile&u=1465
pubmed for peer-reviewed articles:
http://www.ncbi.nlm.nih.gov/pubmed?term=preeclampsia

Please ask more questions and let us know what you find!
Heather, mom to
#1 7-18-03 - 5#8oz 37 weeks PE/PIH
#2 8-11-06 - 6#14oz 37 weeks PE/PIH
#3 9-10-09 - 5#10oz 37 weeks PE/PIH

rodin
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Posts: 6
Joined: Sat Dec 17, 2011 7:51 am

Is this the pathophysiology of preeclampsia?

Postby rodin » Sat Dec 17, 2011 10:44 am

:o Does this article explain the pathophysiology of preeclampsia? :?

Shortly summarized the hypothesis explained is:
Compression or kinking of the left renal vein --> activation of the Renin angiotensin system --> general arteriolar vasoconstriction --> organ and placenta hypoxemia --> vascular damage --> organ damage and preeclampsia symptoms.

http://philica.com/display_article.php?article_id=240

If this turns out to be right, pregnant women should probably be advised to sleep on there left side. :idea:


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