Upregulation of sFlt-1 by trophoblasts induces the barrier d

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Upregulation of sFlt-1 by trophoblasts induces the barrier d

Postby caryn » Sun Dec 18, 2011 05:18 pm

It was concluded that the dysregulation of sFlt-1 and VEGF in preeclamptic pregnancy may contribute to the barrier dysfunction of glomerular endothelial cells, and VEGF may play an important role in maintaining the barrier function of glomerular endothelial cells, but it may not be the sole factor.

http://www.ncbi.nlm.nih.gov/pubmed/22173504

So this is another study suggesting that the damage to the kidneys ("glomerular endotheliosis") is caused by upregulation of sFlt-1 binding to VEGF and pulling it out of circulation. That's why the podocyte urine screening test is really measuring the same thing as the soluble factors tests in development.
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DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy
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Re: Upregulation of sFlt-1 by trophoblasts induces the barri

Postby kerisue » Tue Dec 20, 2011 10:20 pm

okay, so vegf is good, sflt1 is bad... what can we DO about it?? (this is a rhetorical question as I know no one has the answer)
Mama to Millie
born June 2010 @ 24 wks. gestation due to my severe PE and CHF
lived 25 days, loved and missed
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Re: Upregulation of sFlt-1 by trophoblasts induces the barri

Postby caryn » Wed Dec 21, 2011 08:19 pm

It would be so good just to know the trainwreck is out there, kwim? If we can get a screening test out of this finally, instead of waiting for women to develop symptoms and crash, then we can plan ahead for the needs. The NICU. The steroids. The MFM.

Heck, I'd be happy to see anything that made them stop sending us home with the suggestion that we're being hypervigilant and paranoid and doing it wrong and that's why our blood pressure is up. :evil:
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies? Lectures from researchers?
A chance to participate in research? For us on Facebook or Twitter?

Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy
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Re: Upregulation of sFlt-1 by trophoblasts induces the barri

Postby MissingMolly » Thu Dec 22, 2011 03:08 am

caryn wrote: Heck, I'd be happy to see anything that made them stop sending us home with the suggestion that we're being hypervigilant and paranoid and doing it wrong and that's why our blood pressure is up. :evil:


Agreed!
Mommy to Molly, who was born alive on Oct. 29, 2011 at 23+3 weeks due to severe pre-eclampsia/HELLP syndrome and passed away 3 hours later. Loved and missed every minute of every day...."If love could have saved you, you would have lived forever."
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