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Can pre-e be genetic through the father?

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Can pre-e be genetic through the father?

Postby Petunia » Tue May 01, 2012 06:45 pm

by Petunia (60 Posts), Tue May 01, 2012 06:45 pm

My sister in law (husband's sister) has 2 kids and is pregnant with her third, as far as I know she never had any pre-e issues with her first two, but now with her 3rd she is having a c-section tonight because her blood pressure was up in the 140's and her platelets are too low...sounds an awful lot like pre-e to me. I've never had any in my family before me, so now I'm wonder, could it have come genetically through my husband's family?
Married the love of my life 7/11/2009
Our first child, Peyton Mark, was born sleeping at 33 weeks on Oct. 25th 2011. Developed pre-e at 32 weeks.
Pregnant again with what I pray is our rainbow baby, due Oct. 14th 2012. Will induce labor no later than 38 weeks if we make it that far!
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Re: Can pre-e be genetic through the father?

Postby caryn » Tue May 01, 2012 09:57 pm

by caryn (10131 Posts), Tue May 01, 2012 09:57 pm

It's known to be what they call "multifactorial polygenic inheritance" which means you have to hit on a combination of genes in the mother and a combination of genes in the father. This won't happen in all pregnancies, because only half the paternal and maternal genes make it into any given blastocyst.

So, say I had to have the genes for chronic hypertension plus an immune mediated condition, and DH had to have the genes for a slightly deranged implantation in the set that were in that particular spermatazoa, and when you put all of those together, the pregnancy is preeclamptic.

This could happen in the third pregnancy, or the second pregnancy, for the first time. It's also the case that some women will develop underlying conditions as they age - chronic hypertension or autoimmune conditions are the likely culprit here - and that those underlying conditions mean the implantation of an otherwise normal placenta isn't tolerated by the mother's body.

So, short answer: yes, but also the mother.
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
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Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy
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