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a key to maternal tolerance of the fetal allograft?

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a key to maternal tolerance of the fetal allograft?

Postby caryn » Tue May 01, 2012 05:52 pm

by caryn (10124 Posts), Tue May 01, 2012 05:52 pm

We have shown that phagocytosis of trophoblast debris from normal placentae alters the phenotype of macrophages such that they are likely to deviate maternal immune responses towards tolerance and away from inflammation. This may be one of the mechanisms that allow the human fetal allograft to survive in direct contact with the maternal immune system...

http://www.ncbi.nlm.nih.gov/pubmed/22542910

So in normal pregnancies, when your white blood cells sweep up the bits of material that are released into your bloodstream by the placenta, that turns down inflammatory cytokines and turns up anti-inflammatory cytokines. The placenta is signalling the maternal immune system to calm the heck down.

In our pregnancies, this does not happen properly.
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
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Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy
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Re: a key to maternal tolerance of the fetal allograft?

Postby kerisue » Wed May 02, 2012 06:59 pm

by kerisue (623 Posts), Wed May 02, 2012 06:59 pm

so no answers about how to make it happen properly?
Mama to Millie
born June 2010 @ 24 wks. gestation due to my severe PE and CHF
lived 25 days, loved and missed
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Re: a key to maternal tolerance of the fetal allograft?

Postby caryn » Wed May 02, 2012 11:04 pm

by caryn (10124 Posts), Wed May 02, 2012 11:04 pm

This confirms our current understanding - which is important, because if it didn't we'd know we were on the wrong track! - that the placenta is producing the signalling that doesn't have that effect in the mother's body.

That could be because the placenta is sending the wrong signals. That could be because the mother's body isn't receiving them properly. That could be a combination of the two. Most genetic analyses that I've seen think it's both, most of the time, because of the way the inheritance patterns are working, with a stronger influence from maternal predisposition but a substantial parental contribution as well.
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies? Lectures from researchers?
A chance to participate in research? For us on Facebook or Twitter?

Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy
User avatar
caryn
Forum Moderator
 
Posts: 10124
Joined: Fri Jun 25, 2004 06:36 am


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