This confirms our current understanding - which is important, because if it didn't we'd know we were on the wrong track! - that the placenta is producing the signalling that doesn't have that effect in the mother's body.
That could be because the placenta is sending the wrong signals. That could be because the mother's body isn't receiving them properly. That could be a combination of the two. Most genetic analyses that I've seen think it's both, most of the time, because of the way the inheritance patterns are working, with a stronger influence from maternal predisposition but a substantial parental contribution as well.
a key to maternal tolerance of the fetal allograft?
Re: a key to maternal tolerance of the fetal allograft?
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies?
A chance to participate in research? For us on Facebook or Twitter?
Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies?
A chance to participate in research? For us on Facebook or Twitter?
Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy
Re: a key to maternal tolerance of the fetal allograft?
so no answers about how to make it happen properly?
Mama to Millie
born June 2010 @ 24 wks. gestation due to my severe PE and CHF
lived 25 days, loved and missed
born June 2010 @ 24 wks. gestation due to my severe PE and CHF
lived 25 days, loved and missed
a key to maternal tolerance of the fetal allograft?
We have shown that phagocytosis of trophoblast debris from normal placentae alters the phenotype of macrophages such that they are likely to deviate maternal immune responses towards tolerance and away from inflammation. This may be one of the mechanisms that allow the human fetal allograft to survive in direct contact with the maternal immune system...
http://www.ncbi.nlm.nih.gov/pubmed/22542910
So in normal pregnancies, when your white blood cells sweep up the bits of material that are released into your bloodstream by the placenta, that turns down inflammatory cytokines and turns up anti-inflammatory cytokines. The placenta is signalling the maternal immune system to calm the heck down.
In our pregnancies, this does not happen properly.
http://www.ncbi.nlm.nih.gov/pubmed/22542910
So in normal pregnancies, when your white blood cells sweep up the bits of material that are released into your bloodstream by the placenta, that turns down inflammatory cytokines and turns up anti-inflammatory cytokines. The placenta is signalling the maternal immune system to calm the heck down.
In our pregnancies, this does not happen properly.
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies?
A chance to participate in research? For us on Facebook or Twitter?
Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies?
A chance to participate in research? For us on Facebook or Twitter?
Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy
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