Free leptin index and PAPP-A: a first tri test

The Preeclampsia Foundation does not necessarily endorse any research or news found in this forum, we just want to share what is out there. Please use your own discretion to evaluate any information you find here.

Free leptin index and PAPP-A: a first tri test

Postby caryn » Mon Dec 21, 2009 10:25 am

fLI was significantly (p < 0.001) elevated [mean log MoM 0.2165 (SD: 0.2604)] compared to controls [mean log MoM -0.0368 (SD: 0.3132)] and PAPP-A was significantly (p < 0.001) reduced [mean log MoM -0.0133 (SD: 0.2661)] compared to controls [mean log MoM 0.0474 (SD: 0.2521)] in PE pregnancies. There was no correlation between fLI and PAPP-A in control or PE pregnancies. Combined fLI and PAPP-A screening for PE had estimated population detection rates of 22% and 35% for false positives rates of 6% and 12%, respectively.

Heh. This disease is so weird. These two serum values that are often off in PE -- but that aren't off *together*, that don't vary together -- work pretty well if you combine them for a detection test. Not great, but better than if you measure them alone. But the variables don't move together (they're "not correlated"), and so that's odd. (You'd think they'd go up or down or inversely proportional to each other together, but they don't.)

Information provided on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disorder, or prescribing any medication. The Preeclampsia Foundation presents all data as is, without any warranty of any kind, express or implied, and is not liable for its accuracy, for mistakes or omissions of any kind, nor for any loss or damage caused by a user's reliance on information obtained on the site. Professional opinions on this condition vary greatly. The Preeclampsia Foundation endorses no one course of treatment or "cure".
User avatar
Forum Moderator
Posts: 10099
Joined: Fri Jun 25, 2004 06:36 am

Return to Announcements and Preeclampsia in the News

Who is online

Users browsing this forum: No registered users and 2 guests